Gas-Filled Liposomes as Ultrasound Contrast Agents for Blood Pool, Thrombus-Specific and Therapeutic Applications
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چکیده
Abstract: We have developed phospholipid-coated microbubbles as ultrasound contrast agents. By incorporating ligands into the vesicle surface, targeted contrast agents have been prepared. Encouraging results have been obtained with thrombus-specific microbubbles for diagnosis and detection of thrombosis. These thrombus-specific microbubbles increase the rate of sonothrombolysis and accelerate clot lysis. A variety of different drugs have been incorporated into microbubbles. Site-specific drug release is obtained in the insonation region.
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تاریخ انتشار 1998